Philippe Grandjean og kolleger har i går publiceret en omfattende undersøgelse, der viser at fluorstoffer (PFCer) hæmmer effekten af børnevacciner. Undersøgelsen, der er lavet på difteri og stivkrampe antistoffer (dem der skal dannes, for at barnet er beskyttet mod sygdommen), viste at børn med meget høje niveauer af PFCer i blodet (eller hvis mødre havde meget høje niveauer af PFCer under graviditeten), havde en dårligere immunitet overfor de to sygdomme efter vaccination. Så dårlig, at vaccinen i nogle tilfælde ikke beskyttede godt nok.
Grandjean og co. har målt på den type af fluorstoffer der i dag er den “gammeldags” type – dvs dem, der er udfaset eller er på vej mod en udfasning. Industrien er begyndt at bruge andre typer PFCer istedet – de nye polyfluorerede udgangsstoffer, fluortelomer alkoholerne (FTOH : F(CF2)nCH2CH2OH) og derivater heraf, f.eks. diPAPs som bruges i emballage, og som kan omdannes til de “gammeldags” perfluorerede stoffer i kroppen.
I kroppen kan de fluorerede stoffer binde sig kraftigt til proteiner i bl.a. blod, nyrer og lever, og i meget høje niveauer kan det give skader i form af kræft i lever, nyrer og bryst. I lavere doser kan der også ske en ændring af enzymerne i leveren, som påvirker det hormonelle system, og dermed kan de virke hormonforstyrrende. Sammenhæng mellem indhold af PFC’ere i blod og forhøjet cholesterol, ADHD og fedme er også blevet fundet i andre studier.
Her kan du læse Ph.D. Xenia Triers svar på læser spørgsmål om fluorstoffer: Sådan tjekker du selv emballagen
Læs mere her: http://videnskab.dk/krop-sundhed/udbredte-kemikalier-haemmer-bornevaccinationer
Læs originalartiklen: JAMA. 2012;307(4):391-397.
Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds
- Philippe Grandjean, MD, DMSc;
- Elisabeth Wreford Andersen, PhD;
- Esben Budtz-Jørgensen, PhD;
- Flemming Nielsen, PhD;
- Kåre Mølbak, MD, DMSc;
- Pal Weihe, MD;
- Carsten Heilmann, MD, DMSc
Abstract
Context Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood.
Objective To determine whether PFC exposure is associated with antibody response to childhood vaccinations.
Design, Setting, and Participants Prospective study of a birth cohort from the National Hospital in the Faroe Islands. A total of 656 consecutive singleton births were recruited during 1999-2001, and 587 participated in follow-up through 2008.
Main Outcome Measures Serum antibody concentrations against tetanus and diphtheria toxoids at ages 5 and 7 years.
Results Similar to results of prior studies in the United States, the PFCs with the highest serum concentrations were perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Among PFCs in maternal pregnancy serum, PFOS showed the strongest negative correlations with antibody concentrations at age 5 years, for which a 2-fold greater concentration of exposure was associated with a difference of −39% (95% CI, −55% to −17%) in the diphtheria antibody concentration. PFCs in the child’s serum at age 5 years showed uniformly negative associations with antibody levels, especially at age 7 years, except that the tetanus antibody level following PFOS exposure was not statistically significant. In a structural equation model, a 2-fold greater concentration of major PFCs in child serum was associated with a difference of −49% (95% CI, −67% to −23%) in the overall antibody concentration. A 2-fold increase in PFOS and PFOA concentrations at age 5 years was associated with odds ratios between 2.38 (95% CI, 0.89 to 6.35) and 4.20 (95% CI, 1.54 to 11.44) for falling below a clinically protective level of 0.1 IU/mL for tetanus and diphtheria antibodies at age 7 years.
Conclusion Elevated exposures to PFCs were associated with reduced humoral immune response to routine childhood immunizations in children aged 5 and 7 years.
